RNA processing involves various stages such as transcription, capping, splicing, and polyadenylation. Processing of RNA is highly regulated and involves hundreds of RNA binding proteins, non coding RNAs, and structural elements. Deciphering the mechanisms of RNA processing contributes to our basic understanding of living cells, as well as to our ability to target specific regulatory elements for therapeutic interventions. Deciphering of RNA processing at the Institute for RNA Innovations involves dozens of labs and a combination of experimental technology development, computational modeling, genomic and genetic data generation, integration, and subsequent analysis for validations and subsequent discoveries. Research on RNA processing is highly integrated with other groups in the RNA institutes across both Basic Science and Therapeutics areas.