Montserrat C. Anguera, Ph.D.
Associate Professor, Department of Biomedical Sciences (University of Pennsylvania School of Veterinary Medicine)
Our laboratory investigates X-chromosome Inactivation, and how this epigenetic process contributes to female-biased autoimmunity.
We are investigating how female lymphocytes maintain X-chromosome Inactivation, which is an epigenetic process responsible for equalizing gene expression between sexes. X-chromosome Inactivation silences one X-chromosome in female cells, and this process is initiated and maintained by the long noncoding RNA Xist.