James Eberwine Ph. D.

Overall, my lab has been interested in the role of variability within cells as a driver of biology and to address the omics of this, we developed the nucleic acid amplification procedures that enabled the field of single cell transcriptomics.  Our current work focuses on understanding the subcellular organelles that interact to give rise to the emergent properties of cells. Much of this relies upon RNA biology and as such we have been developing methodologies, that permit quantitative analysis and functionalization of multi-RNAs and their modifications in individual organelles.

Keywords: single cell, single organelle, RNA biologies